Proton tunneling in hydrogen bonds and its implications in an induced-fit model of enzyme catalysis
نویسندگان
چکیده
Onur Pusuluk, Tristan Farrow, 3 Cemsinan Deliduman, Keith Burnett, and Vlatko Vedral 3 Department of Physics, İstanbul Technical University, Maslak, İstanbul, 34469 Turkey Department of Physics, University of Oxford, Parks Road, Oxford, OX1 3PU, UK Centre for Quantum Technologies, National University of Singapore, 3 Science Drive 2, Singapore 117543, Singapore Department of Physics, Mimar Sinan Fine Arts University, Bomonti, İstanbul, 34380, Turkey University of Sheffield, Western Bank, Sheffield S10 2TN, UK (Dated: March 3, 2017)
منابع مشابه
Measurement of proton tunneling in short hydrogen bonds in single crystals of 3,5 pyridinedicarboxylic acid using nuclear magnetic resonance spectroscopy.
In this Letter, we present NMR spin-lattice and relaxometry data for proton transfer in one of the shortest known N-H⋯O hydrogen bonds in a single crystal of 3,5 pyridinedicarboxylic acid (35PDCA). It is widely believed that proton transfer by quantum tunneling does not occur in short hydrogen bonds since the ground state energy level lies above the potential barrier, yet these data show a temp...
متن کاملQuantum Tunneling in DNA
DNA contains all of the genetic information necessary to grow and sustain life and it is designed in such a way as to be remarkably stable despite it’s complexities. This paper discusses the inherent quantum mechanical nature of the hydrogen bonds in DNA nucleotides, specifically the occurrence of proton tunneling within the hydrogen bond and the implications this has on the integrity of DNA re...
متن کاملThe Effect of Hydrogen Bonding and π–π Stacking to Stabilization of 3D Networks of a New Proton Compound, (a-6-mpyH)(Hpyzd) H2O
A new proton transfer compound, formulated as (Hamp-6-pic)(Hpyzd) ∙H2O (1), has been synthesized from the reaction of pyrazine-2,3-dicarboxylic acid (H2pyzd) and 2-amino-6-methyl pyridine (amp-6-pic), in 1:1 molar ratio. Extensive O−H×××O, N−H×××N and O−H×××O hydrogen bonds involving (Hamp-6-pic)+ cation, (Hpyzd)- anion and co-crystal water molecule٫ static electronic٫ and π…π stacking interac...
متن کاملOn the Possibility of Detecting Low Barrier Hydrogen Bonds with UV Spectroscopy and Kinetic Measurements
Recent Experimental evidence has pointed that in many enzyme-catalyzed biochemical pathways a short, strong hydrogen bond between an enzyme and substrate leads to an important contribution to enzyme catalysis. These bonds are termed low barrier hydrogen bonds. In this paper we show that the presence of low barrier hydrogen bonds can be determined in systems by UV spectroscopy and kinetic measur...
متن کاملKinetic Isotope Effects as Probes for Hydrogen Tunneling, Coupled Motion and Dynamics Contributions to Enzyme Catalysis
Since the early days of enzymology attempts have been made to deconvolute the various contributions of physical phenomena to enzyme catalysis. Here we present experimental and theoretical studies that examine the possible role of hydrogen tunneling, coupled motion, and enzyme dynamics in catalysis. In this review, we first introduce basic concepts of enzyme catalysis from a physical chemistry p...
متن کامل